CAWorks-pipeline-human heart

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Human Heart Shape Analysis Pipeline

Average ventricular shapes (templates) were constructed for end-systole and end-diastole cardiac phases




  • Isotropic Preprocessing* - Transform the heart volumes to have the same resolution/spacing in three spatial directions.
  • LDDMM-volume* - Software tool developed at JHU Center for Imaging Science that computes a mapping from one volume to another using large deformation diffeomorphic metric mapping.
  • Templates* - Average Ventricular Shapes (Templates) were constructed for end-systole and end-diastole cardiac phases.

Image Acquisition Protocol

Each subject was studied in a 64-detector MDCT scanner. Imaging was performed using a retrospectively electrocardiogram gated MDCT protocol with the following parameters: gantry rotation time = 400 ms; detector collimation = 0.5 mm 32 (plane resolution varied from 0.36 mm x 0.36 mm to 0.45 x 0.45 mm, thickness = 0.5 mm). Axial images were reconstructed using a multi-segment reconstruction algorithm at 10 time points (the center of the reconstruction window between 0% and 90% of the cardiac cycle, at 10% intervals).


All patients had left ventricular ejection fraction (LVEF) < 35% on the basis of a clinically indicated non-MRI study, and all patients had undergone coronary angiography. Patients were classified as (non-ischemic cardiomyopathy) NICM if they had no history of myocardial infarction (MI) or revascularization, and no evidence of coronary artery stenosis > 50% of 2 or more epicardial vessels or left main or proximal left anterior descending (LAD) coronary artery stenosis > 50%. Patients with significant coronary LAD artery stenosis and a history of anterior MI were classified as having ischemic cardiomyopathy (ICM).

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